Key Vaccine Information

Saturday, March 12, 2011

Flu, Pneumococcal vaccine increases risk of febrile seizure

Children 6 to 23 months of age who receive trivalent inactivated flu vaccine (TIV) concurrently with the 13-valent pneumococcal conjugate vaccine (PCV13) are at increased risk of febrile seizures, according to researchers at the Centers for Disease Control and Prevention (CDC) in Atlanta and Harvard Medical School in Boston.

Frank DeStefano, MD, MPH, director of the CDC’s Immunization and Safety Office, and Grace M. Lee, MD, MPH, assistant professor of Population Medicine at Harvard Medical School, presented their findings at a recent meeting of the CDC’s Advisory Committee on Immunization Practices (ACIP) in Atlanta. DeStefano noted that fever after vaccination is common and might increase the risk of febrile seizures. He estimated that when given concurrently, TIV and PCV13 might account for approximately 60 seizures per 100,000 children and that such seizures typically occur the day after vaccination.

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